A manuscript in the hand of 'David ap Griffith effyriad' (see pp. 13, 14) containing medical precepts and prescriptions (pp. 15-27, 54-92), material of botanological (pp. 28-40), physiological (pp. 41-49) and theological (pp. 1-12) interest, and poetry (pp. 13-14, 50-53). The section on botany includes a Latin-Welsh vocabulary of plant names. Poetical works cited are those of Taliesin, Dafydd ap Gruffydd and Gruffudd Gryg.
There are traces of the hand of Sir Thomas Wilems (p. 40), and also of another hand on many folios.

A manuscript containing medical recipes, lists of names of medicinal plants, etc.
Much of the text agrees practically with that of the Meddygon Myddfai, but the order is quite different, and the wording varies also.

A manuscript containing poetry (pp. 17-42), the poets including Taliesin, Iolo Goch, Dafydd ab Edmwnt and others, with poetry included also within other sections of the text; triads attributed to Taliesin (p. 16); the Rood legend (pp. 97-103); apocryphal gospels (pp. 104-153, 259-269, 272, 274-276); the Purgatory of Patrick (pp. 202-212); lives of saints (pp. 161-187); proverbs and adages, etc. (pp. 10-12, 14-15, 299-300); prayers (pp. 13, 238-250, 255); vocabulary (pp. 95-96); a planisphere, calendar, planetary tables and other astrological material (pp. 43-86, 89-90, 281-291); interpretation of dreams (pp. 91, 94); palmistry (pp. 92-93); directions concerning bleeding, medical recipes, etc. (pp. 1-9, 87-88, 236, 277-280, 300c-301); &c. A note on p. 221 states that 'Ieuan ap William ap dd: ap ejnws ajysgrivenodd yllyvr hwn i gyd ari gost ihvn i gael o bobyl ddifyrwch o hono alles yw heneidiav o hwn'; there are, however, a few pages (pp. 139-142, etc.) in other hands. There is a table of contents at the beginning in the hand of Richard Morris, 1784-1785, and another at the end by ?William Jones, who states that the manuscript was 'procured me by Mr. Holmes of the Tower'.
The dates appended to many of the subjects in the text show that the binder is responsible for the present derangement of the folios.

A manuscript in the autograph of Dr John David Rhys (1534-1609) containing mainly notes relating to castles, historical figures, etc.; together with poetry of Siôn Tudur (p. 5)

A manuscript, 'ex Autographo D'ni H. Salesbury de Llan rwst penes dnm R. Salesbury de Rug', containing pedigrees and poetry.
Pp. 1-22 are in the hand of David Parry, and pp. 23-36 probably also in his hand. The poets cited include Taliesin, Sion Tudur and Dafydd ab Edmwnd.

A manuscript containing pedigrees, which includes a list of the mothers of Welsh princes and their children.

A manuscript containing pedigrees written, at least in part, in 1633 (see p. 68).
There are several lacunae in the text.

A manuscript containing Brut y Tywysogion; measurements of Britain; the Twenty-four Knights of King Arthur's court; the pedigrees of British kings and rulers; etc.

A volume in the hand of Evan Evans (Ieuan Fardd) containing pedigrees and genealogy (pp. 1-93, 117-133), including transcripts from Heraldic Visitations of Wales, Vol. II, pp. 67, 83, 97-111, 104-105, 107-109, 119, 122, 139-140, 285, 290-291 (pp. 1-21, 57-93, 131-133); words added by Dr John Davies, Mallwyd, to his Dictionary (pp. 97-110) and his additions to the Welsh proverbs (pp. 111-116); historical extracts (pp. 155-180, 210-230); etc.
The text beginning at p. 210 is from a manuscript of Wiliam Llŷn and contains Annales Oweni Glyndwr (see NLW MS 1991B and Peniarth MS 267, pp. 4-14).

A manuscript, in the hand of Evan Evans (Ieuan Fardd), containing 'Cerddwriaeth Simwnt Fychan' (ff. 1-43 verso, first sequence) and the 'Rhetoreg' of William Salesbury, which was originally a translation of a Latin treatise on rhetoric (ff. 1-47, second sequence).
There are copious references to the source materials for both parts, the names mentioned including John Jones, Gellilyfdy, William Maurice and Roger Morris (ff. 1 (first sequence), 46 verso (second sequence)). A note by Ieuan Fardd states that he transcribed these works in 1776 (f. 46 verso). For Simwnt Fychan's 'Cerddwriaeth' see also Peniarth MS 159 and Jesus College MS 9.

An imperfect manuscript in several hands containing Welsh poetry, including the works of Tudur Aled, Siôn Brwynog, Simwnt Fychan and others.

A manuscript containing the poetry of Dafydd ab Edmwnd, Iolo Goch, Rhys Nanmor, Dafydd ap Gwilym and others.
This manuscript is part of another manuscript and is written in the same hand as Peniarth MS 47. The cywyddau contained here are numbered 64-108.

A manuscript containing poetry of the fifteenth and sixteenth centuries and including the works of Gruffydd Gryg, Guto'r Glyn, Tudur Aled, Siôn Phylip and others, some of the cited works being incomplete.
The manuscript is written in two hands: pp. 1-164 were written c. 1630, while pp. 169-258 were written towards the end of the sixteenth century. On p. 1 there is a table of contents in the hand of Lewis Morris.

A manuscript containing poetry of Taliesin, Iolo Goch, Dafydd ap Gwilym, Siôn Cent, Siôn Phylip and others.
Pages 27-128 , 137-278 were written c. 1623 (see p. 176); pp. 283-314a, 315-316, 319-322 somewhat later; and pp. 128b-133, 279-282, 314b-314c, 317-318, 323-366, as well as those pages at the beginning of the manuscript, written c. 1692 (see p. 364). On p. i is a table of contents by Lewis Morris.

A manuscript in the hand of Evan Evans containing poetry mostly derived, indirectly, from the Black Book of Carmarthen (Peniarth MS 1) and the Red Book of Hergest (Oxford, Jesus College MS 111). A table of contents, in a later hand, is on pp. 179-180.
This transcript was adopted by the editors of the Myvyrian Archaiology of Wales for their text or for their notes.

A manuscript containing poetry by Bedo Brwynllys, Dafydd ab Edmwnd, Dafydd ap Gwilym and others in the hand of Samuel Williams.

A manuscript containing Welsh poetry, including the work of Edmwnd Prys, Sion Brwynog, Guto'r Glyn, Sion Phylip, Sion Tudur, Taliesin, Iolo Goch and others. Pp. 7-58, 61-66, 171-210 are in the hand of Roger Williams, assistant to Bishop William Morgan (1545-1604); pp. 131-137 are in the hand of Dr John David Rhys; and pp. 67-112, 139-152 are in the hand of John Powel of Talgarth, Breconshire (see pp. 67, 139; see also Peniarth MSS 27 and 45). P. 58 contains a note, 1611, in the hand of Roger Williams concerning 'the fees that goeth vpon any person in suinge owt his lyveryes', and on p. 61 is a note, 1617, in the same hand concerning the 'benefactors of the Cathedrall church of Landaphe'. Also included in the manuscript is a sermon 'in praise of theves' (p. 197), triads (pp. 200-201) and medical and veterinary recipes (pp. 199, 210b).

Welsh poetry in the same hand as Mostyn MS 160 and Peniarth MS 114. The poets cited include Guto'r Glyn, Sion Phylip, Dafydd Nanmor and Wiliam Llŷn.

A manuscript containing poetry and orations in the hand of Roger Morys, Coed y Talwrn, Llanfair Dyffryn Clwyd. The poetry includes the work of Iolo Goch, Gutun Owain, Madog Benfras and others.